Sustained β-catenin activity in dermal fibroblasts is sufficient for skin fibrosis
نویسندگان
چکیده
Fibrosis is a pathologic process in which deposition of abnormal extracellular matrix by fibroblasts leads to the loss of normal tissue structure and function. In skin, fibrosis is associated with several diseases, including systemic sclerosis, localized scleroderma, nephrogenic systemic fibrosis, and keloid scars. Currently, effective targeted therapies to reverse or prevent fibrosis are lacking.
منابع مشابه
Wnt/β-catenin Signaling Pathway Regulates Specific lncRNAs That Impact Dermal Fibroblasts and Skin Fibrosis
Wnt/β-catenin signaling is required for embryonic dermal fibroblast cell fate, and dysregulation of this pathway is sufficient to promote fibrosis in adult tissue. The downstream modulators of Wnt/β-catenin signaling required for controlling cell fate and dermal fibrosis remain poorly understood. The discovery of regulatory long non-coding RNAs (lncRNAs) and their pivotal roles as key modulator...
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